3-MeO-PCE

3-MeO-PCE (3-Methoxyeticyclidine) is a synthetic chemical compound belonging to the arylcyclohexylamine class, which is known for producing dissociative anesthetic effects. It is structurally related to phencyclidine (PCP) and ketamine, as well as to its close analog, 3-MeO-PCP.

Key Characteristics of 3-MeO-PCE:

1. Chemical Structure:
   • The full name of 3-MeO-PCE is 3-Methoxyethylcyclohexylamine.
   • It is a derivative of eticyclidine (PCE), with a methoxy (-OCH₃) group attached to the 3rd position of the aromatic ring.
2. Mechanism of Action:
   • 3-MeO-PCE is believed to act primarily as an NMDA receptor antagonist, which blocks the activity of NMDA receptors in the brain. This disruption is responsible for its dissociative effects, including altered perception and detachment from reality.
   • It may also have secondary activity at other receptor sites, including dopamine and serotonin receptors, which could contribute to its stimulant and euphoric properties.
3. Psychoactive Effects:
   • Users of 3-MeO-PCE have reported the following effects:
     • Dissociation (detachment from self and environment).
     • Euphoria and mood enhancement.
     • Altered sensory perception (visual, auditory, and tactile changes).
     • Cognitive changes, such as introspection or thought loops.
     • Stimulant-like effects, including increased energy and sociability.
   • The intensity and duration of effects can vary depending on dosage, individual tolerance, and set/setting.
4. Duration:
   • The effects of 3-MeO-PCE generally last longer than ketamine, with an onset of 20-40 minutes and a duration of 4-8 hours depending on the dose and route of administration.
5. Research Chemical:
   • Like many substances in its class, 3-MeO-PCE is categorized as a research chemical with no approved medical or therapeutic use. It is primarily used in experimental or recreational contexts.

Risks and Concerns:

1. Limited Research:
   • Scientific studies on 3-MeO-PCE are scarce, meaning its long-term effects, safety profile, and pharmacokinetics are not well-documented.
2. Potential for Abuse:
   • As a dissociative substance, it has the potential for psychological dependence. Repeated use may lead to tolerance and compulsive behavior.
3. Adverse Effects:
   • Commonly reported negative effects include:  – Confusion and disorientation, Motor impairment or loss of coordination, Anxiety or paranoia, especially at higher doses.